Derivation of Imidazole and Dihydrofuran from a Sponge Iricinia Fusca



Its Scientific Federation pleasure to get an article from author Srinu Meesala  and successfully it has been done with the review process and had published in SciFed journal of Chemical Research.
       The sponge Ircinia fusca was collected from the Arabian Sea, afforded two new metabolites (1-2). The sponge Ircinia fusca (Carter, 1880) was collected from Vayngani, West coast of Maharashtra, India, in Feb 2016. Firstly the sponge was identified by Dr. Satish S.Mokashe he is Associate Professor of Department of Zoology at Dr. Babasaheb Ambedkar Marathwada University, INDIA.
       The author followed Extraction and isolation methods.In this method in the laboratory, firstly the sponge was washed with distilled water to remove surface salts, sand, and epiphytes. The sponge was cleaned with tissue paper to remove excess water, cut into small pieces and placed in a lyophilizer to completely dry. The dried material was (2g) reduced to small pieces and extracted with methanol.Desalting of sponge methanolic extract with acetone. The methanolic extracts were concentrated under vacuum using a rotavapor at 400C followed by a partition with hexane. All the partition layers were subjected to preliminary bioactivity studies (antibacterial & antifungal) by disc diffusion method.
       By using Antimicrobial activity the isolated compounds 1–2 were tested against antibacterial products like Escherichia coli (NCIM 2065), Salmonella typhimurium (NCIM 2501), Bacillus subtilis (NCIM 2063), Staphylococcus aureus (NCIM 2079), Mycobacterium smegmatis (NCIM 5138) and antifungal strains Aspergillus niger (NCIM 1207), Penicillium chrysogenum (NCIM 1315), Alternaria sp (NCIM 900), and Fusarium sp (NCIM 1372) and after testing the remaining crude dissolved in DMSO at a concentration of 1 mg/mL. Therefore 2 compounds were formed by using extraction and isolation methods. The Compound 1 was obtained as white color and the Compound 2 was obtained as pale yellow viscous.
       In this article, the author had explained that how Imidazole and Dihydrofuran Derivative from a Sponge Iricinia Fusca.

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